孙晓辉

姓　　名：孙晓辉

职称职务：副教授

电子邮箱：sunxiaohui@suda.edu.cn

办公地址：云轩楼1229

个人简介：

一、学习工作经历

1、学历背景：

1996.09-2000.07 华中科技大学，精细化工，本科

2000.09-2003.07 华中科技大学，无机化学，硕士

2003.09-2007.07 华中科技大学，生物医学工程，博士

2、国外研究经历：

2008.10-2010.08 英国牛津大学心血管医药系，博士后

2010.09-2013.02 美国华盛顿大学圣路易斯分校生物医学工程系，博士后  

2013.02-2014.02 美国伊利诺伊大学医学院肿瘤生物与药理系，助理研究员   

二、研究方向

(1) 离子通道的结构与功能

(2) 离子通道在神经炎症、神经系统疾病以及肿瘤中的功能和调节

(3) 靶向离子通道的药物和纳米载药系统研究

三、主要研究成果

主要研究电压和钙依赖的大电导钾通道（BK通道）和瞬时受体电位阳离子通道（TRP通道）。近年来发表SCI论文二十余篇。主持国家自然科学基金一项，参与科技部重点研发计划一项。 

1.       代表性论文：

(1)      G. Li^#, L. Hu^#, X. Gu, W. Zhu, X. Zhen, X. Sun*, Targeting large-conductance calcium-activated potassium channels to ameliorate lipopolysaccharide-induced depressive-like behavior in mice, Neurochemical Research. 2024, 49(5): 1239-1253.

(2)      X. Sun*, BK channels in microglia, Brain Science Advances. 2023, 9(1): 15-23.

(3)      T. Li^#, S. Jiang^#, Y. Zhang, J. Luo, M. Li, H. Ke, Y. Deng, T. Yang*, X. Sun*, H. Chen*, Nanoparticle-mediated TRPV1 channel blockade amplifies cancer thermo-immunotherapy via heat shock factor 1 modulation, Nature Communications. 2023, 14(1): 2498.

(4)      X. Yang^#, G. Wang^#, T. Cao, L. Zhang, Y. Ma, S. Jiang, X. Teng, X. Sun*, Large-conductance calcium-activated potassium channels mediate lipopolysaccharide-induced activation of murine microglia, The Journal of Biolgical Chemistry. 2019, 294(35): 12921-12932.

(5)      X. Sun, E. Zakharian*, Regulation of the temperature-dependent activation of transient receptor potential vanilloid 1 (TRPV1) by phospholipids in planar lipid bilayers, The Journal of Biolgical Chemistry. 2015, 290(8): 4741-4747.

(6)      X. Sun, J. Shi, K. Delaloye, X. Yang, H. Yang, G. Zhang, J. Cui*, The interface between membrane-spanning and cytosolic domains in Ca²⁺-dependent K⁺ channels is involved in β subunit modulation of gating, The Journal of Neuroscience. 2013, 33(27): 11253-11261.

(7)      X. Sun^#, M.A. Zaydman^#, J. Cui*, Regulation of voltage-activated K⁺ channel gating by transmembrane β subunits, Frontiers in Pharmacology. 2012, 3: 63.

(8)      L. Xiao^#, X. Xiong^#, X. Sun^#, Y. Zhu, H. Yang, H. Chen, L. Gan, H. Xu, X. Yang*, Role of cellular uptake in the reversal of multidrug resistance by PEG-b-PLA polymeric micelles, Biomaterials. 2011, 32(22): 5148-5157.

(9)      X. Sun, J. Ding, H. Li, N. Pan, L. Gan, X. Yang*, H. Xu, Activation of large-conductance calcium-activated potassium channels by puerarin: the underlying mechanism of puerarin-mediated vasodilation, The Journal of Pharmacology and Experimental Therapeutics. 2007, 323(1): 391-7.

(10)   Y. Nersesyan, L. Demirkhanyan, D. Cabezas-Bratesco, V. Oakes, R. Kusuda, T. Dawson, X. Sun, C. Cao, A.M. Cohen, B. Chelluboina, K.K. Veeravalli, K. Zimmermann, C. Domene, S. Brauchi, E. Zakharian*, Oxytocin Modulates Nociception as an Agonist of Pain-Sensing TRPV1, Cell Reports. 2017, 21(6): 1681-1691.

(11)   S. Asuthkar, P.A. Elustondo, L. Demirkhanyan, X. Sun, P. Baskaran, K.K. Velpula, B. Thyagarajan, E.V. Pavlov, E. Zakharian*, The TRPM8 protein is a testosterone receptor: I. Biochemical evidence for direct TRPM8-testosterone interactions, The Journal of Biolgical Chemistry. 2015, 290(5): 2659-2669.

(12)   S. Asuthkar, L. Demirkhanyan, X. Sun, P.A. Elustondo, V. Krishnan, P. Baskaran, K.K. Velpula, B. Thyagarajan, E.V. Pavlov, E. Zakharian*, The TRPM8 protein is a testosterone receptor: II. Functional evidence for an ionotropic effect of testosterone on TRPM8, The Journal of Biolgical Chemistry. 2015, 290(5): 2670-2688.

(13)   J. Yang, H. Yang, X. Sun, K. Delaloye, X. Yang, A. Moller, J. Shi, J. Cui*, Interaction between residues in the Mg²⁺-binding site regulates BK channel activation, The Journal of General Physiology. 2013, 141(2): 217-228.

(14)   V. Lukacs, J.M. Rives, X. Sun, E. Zakharian, T. Rohacs*, Promiscuous activation of transient receptor potential vanilloid 1 (TRPV1) channels by negatively charged intracellular lipids: the key role of endogenous phosphoinositides in maintaining channel activity, The Journal of Biolgical Chemistry. 2013, 288(49): 35003-35013.

(15)   B. Liu, X. Sun, Y. Zhu, L. Gan, H. Xu, X. Yang*, Biphasic effects of H₂O₂ on BK(Ca) channels, Free Radical Research. 2010, 44(9): 1004-1012.

(16)   W. Wang, W. Xiong, J. Wan, X. Sun, H. Xu, X. Yang*, The decrease of PAMAM dendrimer-induced cytotoxicity by PEGylation via attenuation of oxidative stress, Nanotechnology. 2009, 20(10): 105103.

(17)   B. Liu, L. Gan, X. Sun, Y. Zhu, Z. Tong, H. Xu, X. Yang*, Enhancement of BK(Ca) channel activity induced by hydrogen peroxide: involvement of lipid phosphatase activity of PTEN, Biochimica et Biophysica Acta. 2009, 1788(10): 2174-2182.

(18)   F. Xiong, X. Sun, L. Gan, X. Yang*, H. Xu, Puerarin protects rat pancreatic islets from damage by hydrogen peroxide, European Journal of Pharmacology. 2006, 529(1-3): 1-7.

(19)   H. Ye, X. Yang, L. Gan, X. Sun, H. Xu, Realgar nanoparticles induced cytotoxicity in promyelocytic leukemia HL-60 cells, Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society. 2005, 7: 7714-7717.

2、科研项目

(1) 科技部重点研发计划“纳米前沿”重点专项“工程化细胞微颗粒纳米药物可控制备及其肿瘤治疗新技术”，参与，2023-2027年

(2) 国家自然科学基金青年科学基金项目，31400924，主持，2015-2017年

四、主要荣誉

(1) 苏州大学医学部优秀本科生班主任，2018年

(2) 苏州市高等院校、科研院所紧缺高层次人才，2015年