Shengliang Li

Shengliang Li, Ph.D.

Professor

Department of Pharmaceutics

Email: lishengliang@suda.edu.cn

Biosketch

Prof. S. Li received his Ph.D. degree in Nanomedicine from the National Center for Nanoscience and Technology and Sun Yat-Sen University in 2014. Then, he spent four years (2014-2018) in a postdoctoral appointment at the Institute of Chemistry of the Chinese Academy of Sciences, the University of Massachusetts Medical School, and Houston Methodist Research Institute of Cornell University. In 2018-2021, Prof. S. Li joined the City University of Hong Kong as a Senior Research Associate and group leader in the Department of Chemistry. He has co-authored 90 papers with over 3600 times of citations (H-Index 34) and 3 ESI Highly Cited Papers (ESI 1%). He is a Young Editorial Board Member for Chinese Chemical Letters.

Research Interests

q  Photoactive Drug and Probe: NIR-activated phototherapy (including photothermal therapy, photodynamic therapy, etc.) and bioimaging of cancer and microbes;

q  Drug Delivery and Nanomedicine: Self-Delivery, Supramolecular Drug, and Active Prodrug for Advanced treatments of the serious disease include cancer, infection, etc;

q  X-medical device: Personalized Medicine, Manipulative Drug Administration, and Intelligent Medical Equipment

Research Fund

1. Biodegradable polymer design for near-infrared II phototheranostics of brain glioma, National Natural Science Foundation of China (2022-2025);

2. Shortwave Infrared (SWIR) Imaging and Spectroscopy System for Biomedical Research, The Croucher Foundation (2018-2022);

3. Stable Organic Nanoparticles With High Photothermal Energy Conversion Efficiencies For Biomedical And Energy Applications, Innovation and Technology Support Project (2019-2021);

Select Publications

1.      Yi Yuan,† Zhe Feng,† Shengliang Li,* Zhongming Huang, Yingpeng Wan, Chen Cao, Sien Lin, Lan Wu, Jing Zhou, Liang-Sheng Liao, Jun Qian,* and Chun-Sing Lee*, Molecular Programming of NIR-IIb-Emissive Semiconducting Oligomers for In Vivo High-Contrast Bioimaging Beyond 1500 nm. Adv. Mater.2022, 34, 2201263.

2.      Xiaozhen Li,† Di Zhang,† Guihong Lu*, Tingchao He, Yingpeng Wan, Man-Kit Tse, Can Ren, Pengfei Wang, Shengliang Li*, Jingdong Luo*, Chun-Sing Lee*, Photochemical Synthesis of Nonplanar Small Molecules with Ultrafast Nonradiative Decay for Highly Efficient Phototheranostics. Adv. Mater.2021, 33, 202102799.

3.      Shengliang Li,^† Qingyuan Deng,^† Yachao Zhang,^† Xiaozhen Li, Guohua Wen, Xiao Cui, Yingpeng Wan, Yongwei Huang,* Jiaxiong Chen, Zhonghua Liu, Lidai Wang,* and Chun-Sing Lee*, Rational Design of Conjugated Small Molecules for Superior Photothermal Theranostics in NIR-II Biowindow. Adv. Mater.2020, 32, 2001146.

4.      Yunxia Wang, Shengliang Li,* Pengbo Zhang, Haotian Bai, Liheng Feng, Fengting Lv, Libing Liu,* and Shu Wang* Photothermal-Responsive Conjugated Polymer Nanoparticles for Remote Control of Gene Expression in Living Cells. Adv. Mater.2018, 30: 1705418.

5.      Shuang Tian,† Haotian Bai,† Shengliang Li*, Yafang Xiao, Xiao Cui, Xiaozhen Li, Jihua Tan, Zhongming Huang, Dong Shen, Weimin Liu, Pengfei Wang, Ben Zhong Tang*, Chun-Sing Lee*, Water‐Soluble Organic Nanoparticles with Programable Intermolecular Charge‐Transfer for NIR‐II Photothermal Anti‐Bacterial Therapy. Angew. Chem. Int. Ed. 2021, 133, 11864.

6.      Huan Chen, Shengliang Li,* Min Wu, Kenry, Zhongming Huang, Chun-Sing Lee,* and Bin Liu,* Membrane-Anchoring Photosensitizer with Aggregation-Induced Emission Characteristics for Combating Multidrug‐Resistant Bacteria. Angew. Chem. Int. Ed. 2020, 59, 632.

7.      Shengliang Li,^† Tao Chen,^† Yunxia Wang, Yanyi Huang,* Kirk S. Schanze,* and Shu Wang*, Conjugated Polymer with Intrinsic Alkyne Units for Synergetically Enhanced Raman Imaging in Living Cells. Angew. Chem. Int. Ed. 2017, 56, 13455.

8.      Shengliang Li,^† Haoting Chen,^† Haile Liu,^† Qiankun Ni, Yuan Yuan, Cong Mao, Wei Zhang, Xiaodong Zhang, Weisheng Guo*, Chun-Sing Lee*, and Xing-Jie Liang*, In Vivo Real-Time Evaluation on Pharmaceutical Behavior of PEGylated-Nanomedicine with intrinsic Near-Infrared II Fluorescence. ACS Nano2020, 14, 13681.

9.      Yingpeng Wan,^† Guihong Lu,^† Wei-Chih Wei,^† Yi-Hsuan Huang, Shengliang Li,* Jia-Xiong Chen, Xiao Cui, Ya-Fang Xiao, Xiaozhen Li, Yanhong Liu, Xiang-Min Meng, Hai-Yan Xie, Jinfeng Zhang,* Ken-Tsung Wong,* and Chun-Sing Lee*, Stable Organic Photosensitizer Nanoparticles with Absorption Peak beyond 800 nm and High ROS Yield for Multi-Modality Phototheranostics. ACS Nano2020, 14, 9917.

10.  Xiaozhen Li,^† Lu Liu,^†Shengliang Li,* Yingpeng Wan, Jia-Xiong Chen, Shuang Tian, Zhongming Huang, Ya-Fang Xiao, Xiao Cui, Chengyang Xiang, Xiao-hong Zhang, Weisheng Guo,* Xing-Jie Liang, and Chun-Sing Lee.* Biodegradable π-Conjugated Oligomer Nanoparticles with High Photothermal Conversion Efficiency for Cancer Theranostics. ACS Nano 2019, 13, 12901.

11.  Shuang Tian, Zhongming Huang, Jihua Tan, Xiao Cui, Yafang Xiao Yingpeng Wan, Xiaozhen Li, Qi Zhao, Shengliang Li,* and Chun-Sing Lee*, Manipulating Interfacial Charge-Transfer Absorption of Co-crystal Absorber for Efficient Solar Seawater Desalination and Water Purification. ACS Energy Lett.2020, 5,2698.

12.  Ning Li, Yijian Gao, Boying Li, Dong Gao, Hao Geng, Shengliang Li*, and Chengfen Xing*, Remote Manipulation of ROS-Sensitive Calcium Channel Using Near-Infrared-Responsive Conjugated Oligomer Nanoparticles for Enhanced Tumor Therapy In Vivo. Nano Lett.2022, 10.1021/acs.nanolett.2c01472.

13.  Xiaoxiao Fan, Yirun Li, Zhe Feng, Guoqiao Chen, Jing Zhou, Mubin He, Lan Wu, Shengliang Li,* Jun Qian,* Hui Lin*, Nanoprobes-assisted multi-channel NIR-II fluorescence imaging-guided resection and photothermal ablation of lymph nodes. Adv. Sci.2021, 8, 2003972.

14.  Xiao Cui, Shengzhi Dong, Shengliang Li,* Jinfeng Zhang, Yafang Xiao, Yanhong Liu, Xiangmin Meng, Feng Li,* and Chun-Sing Lee*, Stable π-Radical Nanoparticles as Versatile Photosensitizer for Effective Hypoxia-Overcoming Photodynamic Therapy. Mater. Horiz.2020, 8, 571.

15.  Zhongming Huang,†Jinchao Wei,† Yingpeng Wan, Peng Li,* Jie Yu, Jiayi Dong, Shuangpeng Wang,*  Shengliang Li,* and Chun-Sing Lee*, Marriage of 2D Covalent-Organic Framework and 3D Network as Stable Solar‐Thermal Still for Efficient Solar Steam Generation. Small Methods 2021, 5, 2100036.

16.  Zhongming Huang  Yu‐Hui Luo,* Wu‐Yue Geng  Yingpeng Wan, Shengliang Li,* and Chun-Sing Lee*, Aligned Millineedle Arrays for Solar Power Seawater Desalination with Site-Specific Salt Formation. Small. 2021, 2101487.

17.  Jinchao Wei,† Ying Liu,† Jie Yu,† Ling Chen, Luo Mai, Lele Yang,  Peng Li,* Shengliang Li,* and Xiao-Hong Zhang*, Conjugated Polymers: Optical Toolbox for Bioimaging and Cancer Therapy. Small. 2021, 202103127.

18.  Ya-Fang Xiao,^† Chenyang Xiang,^†Shengliang Li,*Cong Mao, Haoting Chen, Jia-Xiong Chen, Shuang Tian, Xiao Cui, Yingpeng Wan, Zhongming Huang, Xiaozhen Li, Xiao-Hong Zhang, Weisheng Guo* and Chun-Sing Lee.* Single-Photomolecular Nanotheranostics for Synergetic Near-Infrared Fluorescence and Photoacoustic Imaging-Guided Highly Effective Photothermal Ablation. Small. 2020, 16, 2002672.

19.  Xiao Cui,Qi Zhao,Zhongming Huang, Yafang Xiao, Yingpeng Wan, Shengliang Li,* and Chun-Sing Lee*, Water-Splitting Based and Related Therapeutic Effects: Evolving Concepts, Progress, and Perspectives. Small2020, 16, 2004551.

20.  Shengliang Li,^† Qingyuan Deng,^† Xiao Li, Yongwei Huang,* Xiaozhen Li, Fang Liu, Huijuan Wang, Weixia Qing, Zhonghua Liu,* Chun-Sing Lee.* Bis-diketopyrrolopyrrole conjugated polymer nanoparticles as photothermic nanoagonist for specific and synergistic glioblastoma therapy. Biomaterials 2019, 216, 119252.